While celebrations in the great city of Bôme were underway to mark the promotion of a prominent officer in the forces of the Inquisition, it looked as though Seth, a scrappy and determined youth hunting the mysterious Radiant, might at long last reunite with his friends Mélie, Ocoho, and Doc. Unfortunately, a powerful group of Domitors opposed to the Inquisition--and its campaign to rid the world of the Infected--arrives on the scene and incites chaos, preventing the reunion. Seth, himself an Infected, joins with a couple of unlikely allies to face the Domitors in hopes of averting a looming catastrophe.